Gene Variant Detail

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Gene ERBB2
Variant L755A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ERBB2 (HER2) L755A lies within the protein kinase domain of the Erbb2 (Her2) protein (UniProt.org). L755A has been identified in the scientific literature (PMID: 28167203, PMID: 29989854), but has not been biochemically characterized and therefore, its effect on Erbb2 (Her2) protein function is unknown (PubMed, Apr 2020).
Associated Drug Resistance

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Transcript NM_004448
gDNA chr17:g.39723966_39723967delTTinsGC
cDNA c.2263_2264delTTinsGC
Protein p.L755A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001289937 chr17:g.39723966_39723967delTTinsGC c.2263_2264delTTinsGC p.L755A RefSeq GRCh38/hg38
NM_004448 chr17:g.39723966_39723967delTTinsGC c.2263_2264delTTinsGC p.L755A RefSeq GRCh38/hg38
NM_001005862 chr17:g.39724771_39724772delCTinsGC c.2263_2264delCTinsGC p.L755A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 L755A lung non-small cell carcinoma no benefit Neratinib Case Reports/Case Series Actionable In a Phase II trial (SUMMIT), Nerlynx (neratinib) treatment resulted in stable disease with a progression-free survival of 3.6 months in a patient with non-small cell lung cancer harboring ERBB2 (HER2) L755A (PMID: 29420467; NCT01953926). 29420467
Molecular Profile Protein Effect Treatment Approaches
ERBB2 L755A unknown