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|Gene Variant Descriptions||PIK3CA R425L lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). R425L has been identified in the scientific literature (PMID: 28167203), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Apr 2020).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ERBB2 A775_G776insYVMA PIK3CA R425L||lung non-small cell carcinoma||predicted - resistant||Trastuzumab||Case Reports/Case Series||Actionable||In a clinical study, the PIK3CA R425L mutation was identified as a potential resistance mechanism in a non-small cell lung carcinoma patient harboring ERBB2 (HER2) A775_G776insYVMA, that progressed during Herceptin (trastuzumab) treatment (PMID: 28167203).||28167203|