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Gene | TP53 |
Variant | Y205C |
Impact List | missense |
Protein Effect | loss of function |
Gene Variant Descriptions | TP53 Y205C lies within the DNA binding domain of the Tp53 protein (UniProt.org). Y205C demonstrates increased proliferation, migration, invasion, and protein stability in culture (PMID: 37030635) and decreased Tp53 transactivation activity in cultured cells (PMID: 15037740, PMID: 22710932). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon6 TP53 Y205C TP53 mutant TP53 inact mut TP53 Y205C |
Transcript | NM_000546.6 |
gDNA | chr17:g.7674917T>C |
cDNA | c.614A>G |
Protein | p.Y205C |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001126113.2 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001126114.2 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001126113 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001126114 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001126112 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_000546 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7674917T>C | c.614A>G | p.Y205C | RefSeq | GRCh38/hg38 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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