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Gene RET
Variant C609S
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions RET C609S lies within the extracellular domain of the Ret protein (UniProt.org). C609S is predicted to confer a gain of function to the Ret protein, as demonstrated by ligand-independent Ret autophosphorylation in culture (PMID: 16343103).
Associated Drug Resistance
Category Variants Paths

RET mutant RET C609X RET C609S

RET mutant RET act mut RET C609S

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Transcript NM_020975.6
gDNA chr10:g.43113621T>A
cDNA c.1825T>A
Protein p.C609S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406744.1 chr10:g.43113621T>A c.1825T>A p.C609S RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43113621T>A c.1825T>A p.C609S RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43113621T>A c.1825T>A p.C609S RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43113621T>A c.1825T>A p.C609S RefSeq GRCh38/hg38
NM_020630 chr10:g.43113621T>A c.1825T>A p.C609S RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43113621T>A c.1825T>A p.C609S RefSeq GRCh38/hg38
NM_020975 chr10:g.43113621T>A c.1825T>A p.C609S RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43113621T>A c.1825T>A p.C609S RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43113621T>A c.1825T>A p.C609S RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43113621T>A c.1825T>A p.C609S RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43113621T>A c.1825T>A p.C609S RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43113621T>A c.1825T>A p.C609S RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References