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Gene | RET |
Variant | K666E |
Impact List | missense |
Protein Effect | gain of function |
Gene Variant Descriptions | RET K666E lies within the cytoplasmic domain of the Ret protein (UniProt.org). K666E results in increased Erk1/2 phosphorylation and is transforming in culture (PMID: 21690267). |
Associated Drug Resistance | |
Category Variants Paths |
RET mutant RET act mut RET K666E |
Transcript | NM_020975.6 |
gDNA | chr10:g.43114596A>G |
cDNA | c.1996A>G |
Protein | p.K666E |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001406744.1 | chr10:g.43114596A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_001406782.1 | chr10:g.43123762A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_001406743.1 | chr10:g.43114596A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_020975.6 | chr10:g.43114596A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_001406780.1 | chr10:g.43123762A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_001406779.1 | chr10:g.43123762A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_020630.7 | chr10:g.43114596A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_020975.5 | chr10:g.43114596A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_001406759.1 | chr10:g.43114596A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_020975 | chr10:g.43114596A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_020630.5 | chr10:g.43114596A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_001406760.1 | chr10:g.43114596A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_020630 | chr10:g.43114596A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
NM_001406781.1 | chr10:g.43123762A>G | c.1996A>G | p.K666E | RefSeq | GRCh38/hg38 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
RET K666E | gain of function | RET Inhibitor |