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Gene KMT2A
Variant R3903H
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions KMT2A R3903H lies within the SET domain of the Kmt2a protein (UniProt.org). R3903H is predicted to confer a loss of function to the Kmt2a protein function, as demonstrated by loss of histone methyltransferase activity in in-vitro assays (PMID: 28182322).
Associated Drug Resistance

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Transcript NM_005933
gDNA chr11:g.118521970G>A
cDNA c.11708G>A
Protein p.R3903H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005933 chr11:g.118521970G>A c.11708G>A p.R3903H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
KMT2A R3903H loss of function - predicted