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Gene RET
Variant C515W
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET C515W lies within the extracellular domain of the Ret protein (UniProt.org). C515W results in increased cell proliferation, S-phase progression, colony formation, cell migration, Ret autophosphorylation, and ERK1/2 and S6 phosphorylation relative to wild-type Ret in culture (PMID: 25725622).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET C515W

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Transcript NM_020975.5
gDNA chr10:g.43112121C>G
cDNA c.1545C>G
Protein p.C515W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43112121C>G c.1545C>G p.C515W RefSeq GRCh38/hg38
NM_020630 chr10:g.43112121C>G c.1545C>G p.C515W RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43112121C>G c.1545C>G p.C515W RefSeq GRCh38/hg38
NM_020975 chr10:g.43112121C>G c.1545C>G p.C515W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References