Gene Variant Detail

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Gene FGFR1
Variant E360K
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR1 E360K lies within the extracellular domain of the Fgfr1 protein (UniProt.org). E360K has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr1 (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 E360K

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Transcript NM_023110.2
gDNA chr8:g.38421800C>T
cDNA c.1078G>A
Protein p.E360K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017013222 chr8:g.38421800C>T c.1078G>A p.E360K RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38421800C>T c.1078G>A p.E360K RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38421800C>T c.1078G>A p.E360K RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38421800C>T c.1078G>A p.E360K RefSeq GRCh38/hg38
NM_023110 chr8:g.38421800C>T c.1078G>A p.E360K RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38421800C>T c.1078G>A p.E360K RefSeq GRCh38/hg38
XM_006716303 chr8:g.38421800C>T c.1078G>A p.E360K RefSeq GRCh38/hg38
NM_001174063 chr8:g.38421800C>T c.1078G>A p.E360K RefSeq GRCh38/hg38
XM_006716304 chr8:g.38421800C>T c.1078G>A p.E360K RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38421800C>T c.1078G>A p.E360K RefSeq GRCh38/hg38
XM_017013221 chr8:g.38421800C>T c.1078G>A p.E360K RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38421800C>T c.1078G>A p.E360K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References