Gene Variant Detail

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Gene FGFR1
Variant P123S
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR1 P123S lies within the extracellular domain of the Fgfr1 protein (UniProt.org). P123S has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr1 in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 P123S

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Transcript NM_023110.3
gDNA chr8:g.38428427G>A
cDNA c.367C>T
Protein p.P123S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011544448 chr8:g.38428007G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_023110 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_001174065.1 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_006716306 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_006716307.2 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_015850.3 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_011544448.2 chr8:g.38428007G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013224.2 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_006716303 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013221 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_001354367.2 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_001174063 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013224 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013226.1 chr8:g.38428007G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_001174065 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_001354367.1 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013226.2 chr8:g.38428007G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_001174065.2 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_015850 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013223 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013222 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013225.2 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_001354369.2 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_001410922.1 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013225 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_047421569.1 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_015850.4 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_047421570.1 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_006716307 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013225.3 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_017013226 chr8:g.38428007G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_001354369.1 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_006716304 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_006716307.1 chr8:g.38428427G>A c.367C>T p.P123S RefSeq GRCh38/hg38
XM_011544448.1 chr8:g.38428007G>A c.367C>T p.P123S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References