Gene Variant Detail

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Gene FGFR1
Variant V273M
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR1 V273M lies within the extracellular domain of the Fgfr1 protein (UniProt.org). V273M has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr1 in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 V273M

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Transcript NM_023110.3
gDNA chr8:g.38424628C>T
cDNA c.817G>A
Protein p.V273M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017013227 chr8:g.38421885_38421887delGACinsCAT c.817_819delGTCinsATG p.V273M RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_047421570.1 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_011544449 chr8:g.38421885_38421887delGACinsCAT c.817_819delGTCinsATG p.V273M RefSeq GRCh38/hg38
XM_047421572.1 chr8:g.38421885_38421887delGTCinsATG c.817_819delGTCinsATG p.V273M RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_006716303 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_017013221 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_017013227.2 chr8:g.38421885_38421887delGTCinsATG c.817_819delGTCinsATG p.V273M RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_006716304 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_017013222 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_011544450.3 chr8:g.38421885_38421887delGTCinsATG c.817_819delGTCinsATG p.V273M RefSeq GRCh38/hg38
NM_023110 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
NM_001174063 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38424628C>T c.817G>A p.V273M RefSeq GRCh38/hg38
XM_011544450.2 chr8:g.38421885_38421887delGTCinsATG c.817_819delGTCinsATG p.V273M RefSeq GRCh38/hg38
XM_011544450 chr8:g.38421885_38421887delGACinsCAT c.817_819delGTCinsATG p.V273M RefSeq GRCh38/hg38
XM_011544449.1 chr8:g.38421885_38421887delGTCinsATG c.817_819delGTCinsATG p.V273M RefSeq GRCh38/hg38
XM_017013227.1 chr8:g.38421885_38421887delGTCinsATG c.817_819delGTCinsATG p.V273M RefSeq GRCh38/hg38
XM_011544449.2 chr8:g.38421885_38421887delGTCinsATG c.817_819delGTCinsATG p.V273M RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References