Gene Variant Detail

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Gene FGFR1
Variant V460A
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR1 V460A lies within the extracellular domain of the Fgfr1 protein (UniProt.org). V460A has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr1 in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 V460A

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Transcript NM_023110.3
gDNA chr8:g.38418279A>G
cDNA c.1379T>C
Protein p.V460A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011544445.2 chr8:g.38418372A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_017013221 chr8:g.38418279A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
NM_023110 chr8:g.38418279A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38418279A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38418279A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544447 chr8:g.38418372A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_006716303 chr8:g.38418279A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544444 chr8:g.38418372A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544443 chr8:g.38419537A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38418279A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544446.2 chr8:g.38419537A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_047421575.1 chr8:g.38419537A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38418279A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544444.2 chr8:g.38418372A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544447.3 chr8:g.38418372A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544446 chr8:g.38419537A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544447.2 chr8:g.38418372A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38418279A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544443.2 chr8:g.38419537A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544444.1 chr8:g.38418372A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544446.3 chr8:g.38419537A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
NM_001174067 chr8:g.38418372A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
NM_001174067.2 chr8:g.38418372A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38418279A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
NM_001174067.1 chr8:g.38418372A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_006716304 chr8:g.38418279A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544445.3 chr8:g.38418372A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38418279A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_011544445 chr8:g.38418372A>G c.1379T>C p.V460A RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38418279A>G c.1379T>C p.V460A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References