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|Gene Variant Descriptions||ERBB2 (HER2) D417Y lies within the extracellular domain of the Erbb2 (Her2) protein (UniProt.org). D417Y results in decreased cell proliferation and cell viability as compared to wild-type Erbb2 (Her2) in one of two different cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Erbb2 (Her2) protein function is unknown (PubMed, Oct 2019).|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Protein Effect||Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|