Gene Variant Detail

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Gene ERBB2
Variant M916I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ERBB2 (HER2) M916I lies within the protein kinase domain of the Erbb2 (Her2) protein (UniProt.org). M916I demonstrates decreased transformation ability as compared to wild-type Erbb2 (Her2) in one of two different cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Erbb2 (Her2) protein function is unknown (PubMed, Apr 2020).
Associated Drug Resistance

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Transcript NM_004448
gDNA chr17:g.39725729G>C
cDNA c.2748G>C
Protein p.M916I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001289937 chr17:g.39725729G>C c.2748G>C p.M916I RefSeq GRCh38/hg38
NM_004448 chr17:g.39725729G>C c.2748G>C p.M916I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
ERBB2 M916I unknown