Gene Variant Detail

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Gene FGFR3
Variant T394M
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR3 T394M does not lie within any known functional domains of the Fgfr3 protein (UniProt.org). T394M has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr3 (PMID: 29533785) and therefore, is predicted to have no effect on Fgfr3 protein function.
Associated Drug Resistance

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Transcript NM_000142
gDNA chr4:g.1804435C>T
cDNA c.1181C>T
Protein p.T394M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713872 chr4:g.1804435C>T c.1181C>T p.T394M RefSeq GRCh38/hg38
XM_011513422 chr4:g.1804435C>T c.1181C>T p.T394M RefSeq GRCh38/hg38
XM_011513420 chr4:g.1804435C>T c.1181C>T p.T394M RefSeq GRCh38/hg38
NM_000142 chr4:g.1804435C>T c.1181C>T p.T394M RefSeq GRCh38/hg38
XM_006713873 chr4:g.1804435C>T c.1181C>T p.T394M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
FGFR3 T394M no effect - predicted