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|Gene Variant Descriptions||NOTCH1 D1538A lies within LNR repeat 3 of the Notch1 protein (UniProt.org). D1538A has been associated with potential drug resistance (PMID: 29636358), but has not been biochemically characterized and therefore, its effect on Notch1 protein function is unknown (PubMed, Apr 2020).|
|Associated Drug Resistance||Y|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|EML4 - ALK NOTCH1 D1538A||lung non-small cell carcinoma||predicted - resistant||Brigatinib||Case Reports/Case Series||Actionable||In a clinical study, a non-small cell lung carcinoma patient harboring EML4-ALK demonstrated resistance to treatment with Alunbrig (brigatinib), and was subsequently found to have acquired NOTCH1 D1538A (PMID: 29636358).||29636358|