Gene Variant Detail

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Gene FOXL2
Variant K193S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FOXL2 K193S does not lie within any known functional domains of the Foxl2 protein (UniProt.org). The functional effect of K193S is conflicting as it results in nuclear aggregation of Foxl2 protein but demonstrates transcriptional activity similar to wild-type protein in culture (PMID: 19515849).
Associated Drug Resistance

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Transcript NM_023067
gDNA chr3:g.138946144_138946145delCTinsGC
cDNA c.578_579delAGinsGC
Protein p.K193S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_023067 chr3:g.138946144_138946145delCTinsGC c.578_579delAGinsGC p.K193S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FOXL2 K193S unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References