Gene Variant Detail

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Gene HRAS
Variant Q61I
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS Q61I does not lie within any known functional domains of the Hras protein (UniProt.org). Q61I results in decreased Hras GTPase activity and leads to transformation of cells in culture (PMID: 3510078).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS Q61I

HRAS mutant HRAS Q61X HRAS Q61I

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Transcript NM_005343.4
gDNA chr11:g.533873_533875delCAGinsATC
cDNA c.181_183delCAGinsATC
Protein p.Q61I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533873_533875delCAGinsATC c.181_183delCAGinsATC p.Q61I RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533873_533875delCAGinsATC c.181_183delCAGinsATC p.Q61I RefSeq GRCh38/hg38
NM_005343 chr11:g.533873_533875delCTGinsGAT c.181_183delCAGinsATC p.Q61I RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533873_533875delCAGinsATC c.181_183delCAGinsATC p.Q61I RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533873_533875delCAGinsATC c.181_183delCAGinsATC p.Q61I RefSeq GRCh38/hg38
NM_176795 chr11:g.533873_533875delCTGinsGAT c.181_183delCAGinsATC p.Q61I RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533873_533875delCAGinsATC c.181_183delCAGinsATC p.Q61I RefSeq GRCh38/hg38
NM_001130442 chr11:g.533873_533875delCTGinsGAT c.181_183delCAGinsATC p.Q61I RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533873_533875delCAGinsATC c.181_183delCAGinsATC p.Q61I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References