Gene Variant Detail

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Gene HRAS
Variant G13T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions HRAS G13T is hotspot mutation that lies within the GTP-binding domain of the Hras protein (UniProt.org). G13T results in increased Hras GTPase activity and loss of response to GTPase-activating proteins, leading to transformation in Xenopus oocytes (PMID: 8430333).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G13T

HRAS mutant HRAS G13X HRAS G13T

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Transcript NM_005343.4
gDNA chr11:g.534285_534286delGGinsAC
cDNA c.37_38delGGinsAC
Protein p.G13T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.4 chr11:g.534285_534286delGGinsAC c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534285_534286delGGinsAC c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534285_534286delGGinsAC c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534285_534286delGGinsAC c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534285_534286delGGinsAC c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_001130442 chr11:g.534285_534286delCCinsGT c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_176795 chr11:g.534285_534286delCCinsGT c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534285_534286delGGinsAC c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_005343 chr11:g.534285_534286delCCinsGT c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References