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|Protein Effect||loss of function|
|Gene Variant Descriptions||ARID1A negative indicates a lack of the ARID1A gene, mRNA, and/or protein.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ARID1A negative||ovarian clear cell carcinoma||predicted - sensitive||ENMD-2076||Phase II||Actionable||In a Phase II trial, ENMD-2076 treatment resulted a median progression-free survival (PFS) of 4.4 months in patients with ARIDA1A-negative recurrent ovarian clear cell carcinoma and a median PFS of 3.6 months in ARID1A-positive patients, with a statistically significant difference in estimated 6-month PFS rate (0.33 vs 0.12, p=0.023) (PMID: 30108107).||30108107|