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|Protein Effect||loss of function|
|Gene Variant Descriptions||PBRM1 loss indicates loss of the PBRM1 gene, mRNA, and protein.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PBRM1 loss||melanoma||sensitive||unspecified CTLA4 antibody + unspecified PD-1 antibody||Preclinical - Cell line xenograft||Actionable||In a preclinical study, knocking-out PBRM1 in melanoma cells sensitized cells to immune therapy consisted of anti-CTLA4 and anti-PD-1 antibodies in culture and in cell line xenograft models, potentially due to increased sensitivity to T cell-mediated cytotoxicity and a favorable tumor microenvironment (PMID: 29301958).||29301958|