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Gene | FLT3 |
Variant | L601F |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | FLT3 L601F lies within the cytoplasmic domain of the Flt3 protein (UniProt.org). L601F is not transforming in cell culture (PMID: 30651561), and therefore, is predicted to have no effect on Flt3 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
FLT3 mutant FLT3 exon14 FLT3 L601F |
Transcript | NM_004119.3 |
gDNA | chr13:g.28034118G>A |
cDNA | c.1801C>T |
Protein | p.L601F |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004119.2 | chr13:g.28034118G>A | c.1801C>T | p.L601F | RefSeq | GRCh38/hg38 |
NM_004119.3 | chr13:g.28034118G>A | c.1801C>T | p.L601F | RefSeq | GRCh38/hg38 |
NM_004119 | chr13:g.28034118G>A | c.1801C>T | p.L601F | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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