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Gene | FBXW7 |
Variant | W486* |
Impact List | nonsense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | FBXW7 W486* results in a premature truncation of the Fbxw7 protein at amino acid 486 of 707 (Uniprot.org). W486* results in increased tumorigenesis in mouse models (PMID: 24838835), and therefore, is predicted to lead to a loss of Fbxw7 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
FBXW7 mutant FBXW7 inact mut FBXW7 W486* |
Transcript | NM_033632.3 |
gDNA | chr4:g.152326193C>T |
cDNA | c.1457G>A |
Protein | p.W486* |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_024454124.1 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_047415898.1 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_024454123.1 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
NM_033632.3 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
NM_033632 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_011532083 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
NM_001349798.2 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_011532085.3 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_024454123.2 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_011532084 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
NM_018315.4 | chr4:g.152324342C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_011532084.3 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_047415901.1 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
NM_018315 | chr4:g.152324342C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_047415897.1 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_011532085.2 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_047415899.1 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_011532084.2 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_017008362 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
NM_033632.3 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
NM_001349798.1 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_047415900.1 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_011532085 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
NM_018315.5 | chr4:g.152324342C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_024454121.1 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
XM_024454122.1 | chr4:g.152326193C>T | c.1457G>A | p.W486* | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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