Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Gene Variant Descriptions||GATA2 R362Q lies within the GATA-type zinc finger domain 2 of the Gata2 protein (UniProt.org). R362Q results in similar restricted macrophage differentiation, but greater erythroid differentiation compared to wild-type Gata2, leads to reduced transactivation in reporter assays, and fails to inhibit granulocyte differentiation in cell culture (PMID: 26214525, PMID: 28642594), however, is conflicting, as it demonstrates decreased DNA-binding in one study (PMID: 28642594), but shows DNA-binding similar to wild-type in another study (PMID: 26214525), and therefore, its effect on Gata2 protein function is unknown.|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Protein Effect||Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|