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|Gene Variant Descriptions||GATA2 R362Q lies within the GATA-type zinc finger domain 2 of the Gata2 protein (UniProt.org). R362Q results in similar restricted macrophage differentiation, but greater erythroid differentiation compared to wild-type Gata2, leads to reduced transactivation in reporter assays, and fails to inhibit granulocyte differentiation in cell culture (PMID: 26214525, PMID: 28642594), however, is conflicting, as it demonstrates decreased DNA-binding in one study (PMID: 28642594), but shows DNA-binding similar to wild-type in another study (PMID: 26214525), and therefore, its effect on Gata2 protein function is unknown.|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
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