Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene RET
Variant S409Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET S409Y lies within the extracellular domain of the Ret protein (UniProt.org). S409Y results in increased phosphorylation of Akt and Erk, and promotes colony formation in cell culture (PMID: 31364476).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET S409Y

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_020975.6
gDNA chr10:g.43109193C>A
cDNA c.1226C>A
Protein p.S409Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.5 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020975 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020630 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References