Gene Variant Detail

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Gene KDR
Variant T761M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KDR (VEGFR2) T761M lies within the extracellular domain of the Kdr (Vegfr2) protein (UniProt.org). T761M has been identified in sequencing studies (PMID: 26644315, PMID: 27683039, PMID: 30239046), but has not been biochemically characterized and therefore, its effect on Kdr (Vegfr2) protein function is unknown (PubMed, Jul 2020).
Associated Drug Resistance

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Transcript NM_002253
gDNA chr4:g.55098788G>A
cDNA c.2282C>T
Protein p.T761M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002253 chr4:g.55098788G>A c.2282C>T p.T761M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
KDR T761M unknown