Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene HRAS
Variant N116H
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions HRAS N116H lies within a nucleotide-binding region of the Hras protein (UniProt.org). N116H results in increased nucleotide exchange rate in in vitro assays, and is transforming in cell culture (PMID: 3043178, PMID: 1549350).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS N116H

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_005343.4
gDNA chr11:g.533557T>G
cDNA c.346A>C
Protein p.N116H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533557T>G c.346A>C p.N116H RefSeq GRCh38/hg38
NM_176795 chr11:g.533557T>G c.346A>C p.N116H RefSeq GRCh38/hg38
NM_005343 chr11:g.533557T>G c.346A>C p.N116H RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533557T>G c.346A>C p.N116H RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533557T>G c.346A>C p.N116H RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533557T>G c.346A>C p.N116H RefSeq GRCh38/hg38
NM_001130442 chr11:g.533557T>G c.346A>C p.N116H RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533557T>G c.346A>C p.N116H RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533557T>G c.346A>C p.N116H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References