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Gene | FBXW7 |
Variant | Q127* |
Impact List | nonsense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | FBXW7 Q127* results in a premature truncation of the Fbxw7 protein at amino acid 127 of 707 (UniProt.org). Due to the loss of all known functional domains (UniProt.org), Q127* is predicted to result in a loss of function. |
Associated Drug Resistance |
Transcript | NM_033632.3 |
gDNA | chr4:g.152411425G>A |
cDNA | c.379C>T |
Protein | p.Q127* |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_017008362 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
XM_024454124.1 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
XM_024454121.1 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
XM_011532083 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
XM_011532084 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
XM_024454122.1 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
NM_001349798.1 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
NM_033632.3 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
XM_011532085 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
XM_011532085.2 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
NM_033632 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
NM_001257069 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
XM_024454123.1 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
XM_011532084.2 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
NM_001257069.1 | chr4:g.152411425G>A | c.379C>T | p.Q127* | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
FBXW7 Q127* | loss of function - predicted |