Gene Variant Detail

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Gene ERBB2
Variant M774_A775insAYVM
Impact List insertion
Protein Effect gain of function
Gene Variant Descriptions ERBB2 (HER2) M774_A775insAYVM results in the insertion of four amino acids in the protein kinase domain of the Erbb2 (Her2) protein between amino acids 774 and 775 (UniProt.org). M774_A775insAYVM results in constitutive phosphorylation of Erbb2 (Her2) and is transforming in cell culture (PMID: 17311002).
Associated Drug Resistance

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Transcript NM_004448
gDNA chr17:g.39724742_39724743insATATGTAATGGC
cDNA c.2324_2325insATATGTAATGGC
Protein p.Y772_A775dupYVMA
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004448 chr17:g.39724742_39724743insATATGTAATGGC c.2324_2325insATATGTAATGGC p.Y772_A775dupYVMA RefSeq GRCh38/hg38
NM_001289937 chr17:g.39724742_39724743insATATGTAATGGC c.2324_2325insATATGTAATGGC p.Y772_A775dupYVMA RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
ERBB2 M774_A775insAYVM gain of function HER inhibitor (Pan) HER2 Inhibitor