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Gene FLT3
Variant D835I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 D835I lies within the protein kinase domain activation loop of the Flt3 protein (PMID: 11290608). D835I has been demonstrated to promote secondary drug resistance in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 27908881), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 D835X FLT3 D835I

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Transcript NM_004119.3
gDNA chr13:g.28018504_28018505delGAinsAT
cDNA c.2503_2504delGAinsAT
Protein p.D835I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28018504_28018505delGAinsAT c.2503_2504delGAinsAT p.D835I RefSeq GRCh38/hg38
NM_004119 chr13:g.28018504_28018505delTCinsAT c.2503_2504delGAinsAT p.D835I RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28018504_28018505delGAinsAT c.2503_2504delGAinsAT p.D835I RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References