Gene Variant Detail

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Gene NRAS
Variant G12C
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G12C is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12C has not been characterized, but can be predicted to confer a loss of function to the Nras protein based on the effects of HRAS G12C and KRAS G12C, which result in a loss of response to GTPase-activating proteins, and transformation of cultured cells (PMID: 26037647, PMID: 6092966).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G12C

NRAS mutant NRAS exon2 NRAS G12X NRAS G12C

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Transcript NM_002524.5
gDNA chr1:g.114716127C>A
cDNA c.34G>T
Protein p.G12C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114716127C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_002524 chr1:g.114716127C>A c.34G>T p.G12C RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114716127C>A c.34G>T p.G12C RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04916236 Phase I LY3214996 + RMC-4630 Combination Therapy of RMC-4630 and LY3214996 in Metastatic KRAS Mutant Cancers (SHERPA) Recruiting NLD 0
NCT05638698 Phase II Balstilimab + QS21 + TG01 QS21 + TG01 Tg01 Vaccine / Qs-21 Stimulon™ With Or Without Balstilimab As Maintenance Therapy Following Adjuvant Chemotherapy In Patients With Resected Pancreatic Cancer (TESLA) Recruiting USA 0
NCT05726864 Phase Ib/II ELI-002 A Study of ELI-002 7P in Subjects With KRAS/NRAS Mutated Solid Tumors (AMPLIFY-7P) Recruiting USA 0