Gene Variant Detail

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Gene NRAS
Variant Q61L
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS Q61L is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61L results in increase Erk and Mek phosphorylation, and activation of Ck2alpha in cell culture (PMID: 27251789), and is predicted to lead to a loss of Nras protein function based on the effects of HRAS Q61L (PMID: 23487764) and KRAS Q61L (PMID: 26037647).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS Q61L

NRAS mutant NRAS exon3 NRAS Q61X NRAS Q61L

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Transcript NM_002524.5
gDNA chr1:g.114713908T>A
cDNA c.182A>T
Protein p.Q61L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114713908T>A c.182A>T p.Q61L RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713908T>A c.182A>T p.Q61L RefSeq GRCh38/hg38
NM_002524 chr1:g.114713908T>A c.182A>T p.Q61L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
NRAS Q61L loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS Q61L NRAS mut
BRAF G534D NRAS Q61L
BRAF V600E NRAS Q61L
NRAS Q61L PIK3CA E545K