Gene Variant Detail

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Gene TP53
Variant C238_M246del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions TP53 C238_M246del results in the deletion of nine amino acids in the DNA-binding domain of the Tp53 protein from amino acids 238 to 246 (UniProt.org). C238_M246del has been identified in sequencing studies (PMID: 11895856), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 C238_M246del

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Transcript NM_000546.6
gDNA chr17:g.7674229_7674255del27
cDNA c.712_738del27
Protein p.C238_M246delCNSSCMGGM
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001276695.3 chr17:g.7673765_7673791del27 c.712_738del27 p.C238_E246delCPGRDRRTE RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246delCNSSCMGGM RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246del RefSeq GRCh38/hg38
NM_001126118.2 chr17:g.7673765_7673791del27 c.712_738del27 p.C238_E246delCPGRDRRTE RefSeq GRCh38/hg38
NM_001276696.3 chr17:g.7673765_7673791del27 c.712_738del27 p.C238_E246delCPGRDRRTE RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246delCNSSCMGGM RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246delCNSSCMGGM RefSeq GRCh38/hg38
NM_001407269.1 chr17:g.7673765_7673791del27 c.712_738del27 p.C238_E246delCPGRDRRTE RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246delCNSSCMGGM RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7669657_7669683del27 c.712_738del27 p.K238_S246delKSKKGQSTS RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246del RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246delCNSSCMGGM RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246del RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246delCNSSCMGGM RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246delCNSSCMGGM RefSeq GRCh38/hg38
NM_001407263.1 chr17:g.7673765_7673791del27 c.712_738del27 p.C238_E246delCPGRDRRTE RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246delCNSSCMGGM RefSeq GRCh38/hg38
NM_001407271.1 chr17:g.7673765_7673791del27 c.712_738del27 p.C238_E246delCPGRDRRTE RefSeq GRCh38/hg38
NM_001407265.1 chr17:g.7673765_7673791del27 c.712_738del27 p.C238_E246delCPGRDRRTE RefSeq GRCh38/hg38
NM_001276761.3 chr17:g.7673765_7673791del27 c.712_738del27 p.C238_E246delCPGRDRRTE RefSeq GRCh38/hg38
NM_001407267.1 chr17:g.7673765_7673791del27 c.712_738del27 p.C238_E246delCPGRDRRTE RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246del RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246del RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246delCNSSCMGGM RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246del RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246del RefSeq GRCh38/hg38
NM_001276760.3 chr17:g.7673765_7673791del27 c.712_738del27 p.C238_E246delCPGRDRRTE RefSeq GRCh38/hg38
NM_000546 chr17:g.7674229_7674255del27 c.712_738del27 p.C238_M246del RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References