Gene Variant Detail

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Gene FGFR1
Variant Q309*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR1 Q309* results in a premature truncation of the Fgfr1 protein at amino acid 309 of 822 (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), Q309* is predicted to lead to a loss of Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 inact mut FGFR1 Q309*

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Transcript NM_023110.3
gDNA chr8:g.38424520G>A
cDNA c.925C>T
Protein p.Q309*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017013221.1 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
XM_047421570.1 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
XM_017013221 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
NM_001174063 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
NM_023110 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
XM_006716304 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
XM_017013222 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
XM_006716303 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38424520G>A c.925C>T p.Q309* RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References