Gene Variant Detail

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Gene FGFR1
Variant S135F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 S135F lies within the extracellular domain of the Fgfr1 protein (UniProt.org). S135F has been identified in sequencing studies (PMID: 25148578), but has not been biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown (PubMed, Apr 2022).
Associated Drug Resistance

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Transcript NM_023110.2
gDNA chr8:g.38428390G>A
cDNA c.404C>T
Protein p.S135F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017013221 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
NM_001174063 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_017013222 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
NM_023110 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_017013223 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
NM_001354369.1 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
NM_001174065.1 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
NM_015850 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_017013224 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_017013224.2 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_006716307.1 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_006716303 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_017013225 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_006716307 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
NM_001174065 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
NM_015850.3 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_006716306 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
NM_001354367.1 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_006716304 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
XM_017013225.2 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38428390G>A c.404C>T p.S135F RefSeq GRCh38/hg38

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 mutant Advanced Solid Tumor sensitive Pemigatinib Preclinical - Cell line xenograft Actionable In a preclinical study, a variety of cancer cell lines harboring mutations in FGFR1, FGFR2, and/or FGFR3 demonstrated sensitivity to Pemazyre (pemigatinib) in culture and in cell line xenograft models, resulting in inhibition of tumor growth (Cancer Res 2015;75(15 Suppl):Abstract nr 771). detail...
FGFR1 mutant Advanced Solid Tumor predicted - sensitive Debio 1347 Phase I Actionable In a Phase I trial, Debio 1347 treatment resulted in partial response in 10.5% (6/57) and stable disease in 28.1% (16/57) of patients with advanced solid tumors harboring genomic alterations of FGFR1/2/3, including amplifications, fusions, and mutations (PMID: 30745300; NCT01948297). 30745300
FGFR1 mutant transitional cell carcinoma predicted - sensitive Erdafitinib Phase II Actionable In a Phase II trial, Balversa (erdafitinib) treatment resulted in an objective response rate of 42% (40/96, 3 complete response, 37 partial response) and a disease control rate of 80% in patients with metastatic or unresectable urothelial carcinoma harboring FGFR alterations (J Clin Oncol 36, 2018 (suppl; abstr 4503); NCT02365597). detail...
FGFR1 mutant Advanced Solid Tumor predicted - sensitive ICP-192 Phase I Actionable In a Phase I trial, ICP-192 (gunagratinib) was well-tolerated, and resulted in an overall response rate or 33.3% (4/12, 1 complete response, 3 partial response) and a disease control rate of 91.7% (11/12) in patients with advanced solid tumors harboring FGF/FGFR gene aberrations (J Clin Oncol 39, 2021 (suppl 15; abstr 4092); NCT03758664). detail...
Molecular Profile Protein Effect Treatment Approaches
FGFR1 S135F unknown