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|Variant||KMT2A - MAML2|
|Gene Variant Descriptions||KMT2A-MAML2 results from the fusion of KMT2A and MAML2, which may lead to disruption of Notch signaling as indicated by suppression of N1ICD and HES1 in luciferase assays (PMID: 17551948), but does not result in focus formation in cell culture (PMID: 25016062), and therefore, the effect on protein function is unknown. KMT2A-MAML2 has been identified in acute myeloid and lymphoblastic leukemias (PMID: 17551948, PMID: 28535805, PMID: 31343482).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|
|KMT2A - MAML2||unknown|