Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Variant||KMT2A - MAML2|
|Gene Variant Descriptions||KMT2A-MAML2 results from the fusion of KMT2A and MAML2 (PMID: 17551948, PMID: 25016062). KMT2A-MAML2 has been identified in acute myeloid and lymphoblastic leukemias (PMID: 17551948, PMID: 28535805, PMID: 31343482), and thymomas (PMID: 32923872) and may lead to disruption of Notch signaling as indicated by suppression of N1ICD-induced HES1 promoter activation in luciferase assays (PMID: 17551948), but does not result in foci formation in cell culture (PMID: 25016062), and therefore, the effect on protein function is unknown.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|
|KMT2A - MAML2||unknown|