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|Protein Effect||loss of function|
|Gene Variant Descriptions||CBL del exon9 is a CBL splice variant caused by a mutation resulting in the deletion of exon 9 (PMID: 19276253). Del exon9 demonstrates increased ubiquitination and reduced protein stability of Cbl, and failure to suppress Erk phosphorylation in cell culture (PMID: 26152360).|
|Associated Drug Resistance|
|Category Variants Paths||
CBL mutant CBL inact mut CBL del exon9
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|