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Gene | HRAS |
Variant | E62G |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | HRAS E62G lies within the GTP binding domain of the Hras protein (PMID: 21779495). E62G has been identified in the scientific literature (PMID: 19628422, PMID: 35062725), but has not been biochemically characterized and therefore, its effect on Hras protein function is unknown (PubMed, Jun 2024). |
Associated Drug Resistance | |
Category Variants Paths |
HRAS mutant HRAS E62G |
Transcript | NM_005343.4 |
gDNA | chr11:g.533871T>C |
cDNA | c.185A>G |
Protein | p.E62G |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_176795 | chr11:g.533871T>C | c.185A>G | p.E62G | RefSeq | GRCh38/hg38 |
NM_005343 | chr11:g.533871T>C | c.185A>G | p.E62G | RefSeq | GRCh38/hg38 |
NM_176795.4 | chr11:g.533871T>C | c.185A>G | p.E62G | RefSeq | GRCh38/hg38 |
NM_001130442.3 | chr11:g.533871T>C | c.185A>G | p.E62G | RefSeq | GRCh38/hg38 |
NM_176795.5 | chr11:g.533871T>C | c.185A>G | p.E62G | RefSeq | GRCh38/hg38 |
NM_005343.3 | chr11:g.533871T>C | c.185A>G | p.E62G | RefSeq | GRCh38/hg38 |
NM_005343.4 | chr11:g.533871T>C | c.185A>G | p.E62G | RefSeq | GRCh38/hg38 |
NM_001130442.2 | chr11:g.533871T>C | c.185A>G | p.E62G | RefSeq | GRCh38/hg38 |
NM_001130442 | chr11:g.533871T>C | c.185A>G | p.E62G | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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