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|Gene Variant Descriptions||PTEN K330E lies within the C2 tensin-type domain of the Pten protein (UniProt.org). K330E results in suppression of Akt phosphorylation similar to wild-type Pten, however, demonstrates reduced Pten protein stability in cell culture, leads to impaired developmental growth in flies (PMID: 32350270), and results in gain of Pten protein function in a Drosophila wing overgrowth assay (PMID: 34492006), and therefore, its effect on Pten protein function is unknown.|
|Associated Drug Resistance|
|Category Variants Paths||
PTEN mutant PTEN K330E
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|