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Gene | RET |
Variant | W85* |
Impact List | nonsense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | RET W85* results in a premature truncation of the Ret protein at amino acid 85 of 1114 (UniProt.org). Due to the loss of all known functional domains (UniProt.org), W85* is predicted to lead to a loss of Ret protein function. |
Associated Drug Resistance | |
Category Variants Paths |
RET mutant RET inact mut RET W85* |
Transcript | NM_020975.6 |
gDNA | chr10:g.43100639G>A |
cDNA | c.254G>A |
Protein | p.W85* |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001406772.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406787.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406761.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_020975.5 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406777.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406779.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_020630.5 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406771.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406781.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406785.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406783.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406780.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406768.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406778.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_020630.7 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406744.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406760.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406759.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406786.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406788.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406766.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406743.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406769.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406789.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406767.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406765.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406774.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_020975 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406763.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406762.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_020630 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406776.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406775.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406770.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_020975.6 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406773.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406764.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406791.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406782.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
NM_001406790.1 | chr10:g.43100639G>A | c.254G>A | p.W85* | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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