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Gene FBXW7
Variant R224L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 R224L does not lie within any known functional domains of the Fbxw7 protein (UniProt.org). R224L has not been characterized in the scientific literature and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 R224L

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Transcript NM_033632.3
gDNA chr4:g.152346985C>A
cDNA c.671G>T
Protein p.R224L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532085.3 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152346985C>A c.671G>T p.R224L RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References