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Gene | RET |
Variant | D631G |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | RET D631G lies within the extracellular domain of the Ret protein (UniProt.org). D631G does not result in covalent Ret dimerization and demonstrates no transforming activity in cell culture (PMID: 10049754), but has not been fully biochemically characterized and therefore, its effect on Ret protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
RET mutant RET D631G |
Transcript | NM_020975.6 |
gDNA | chr10:g.43114492A>G |
cDNA | c.1892A>G |
Protein | p.D631G |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_020630.7 | chr10:g.43114492A>G | c.1892A>G | p.D631G | RefSeq | GRCh38/hg38 |
NM_020630 | chr10:g.43114492A>G | c.1892A>G | p.D631G | RefSeq | GRCh38/hg38 |
NM_001406760.1 | chr10:g.43114492A>G | c.1892A>G | p.D631G | RefSeq | GRCh38/hg38 |
NM_020975.5 | chr10:g.43114492A>G | c.1892A>G | p.D631G | RefSeq | GRCh38/hg38 |
NM_020975.6 | chr10:g.43114492A>G | c.1892A>G | p.D631G | RefSeq | GRCh38/hg38 |
NM_001406743.1 | chr10:g.43114492A>G | c.1892A>G | p.D631G | RefSeq | GRCh38/hg38 |
NM_020975 | chr10:g.43114492A>G | c.1892A>G | p.D631G | RefSeq | GRCh38/hg38 |
NM_001406744.1 | chr10:g.43114492A>G | c.1892A>G | p.D631G | RefSeq | GRCh38/hg38 |
NM_020630.5 | chr10:g.43114492A>G | c.1892A>G | p.D631G | RefSeq | GRCh38/hg38 |
NM_001406759.1 | chr10:g.43114492A>G | c.1892A>G | p.D631G | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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