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Gene RET
Variant D631G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET D631G lies within the extracellular domain of the Ret protein (UniProt.org). D631G does not result in covalent Ret dimerization and demonstrates no transforming activity in cell culture (PMID: 10049754), but has not been fully biochemically characterized and therefore, its effect on Ret protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RET mutant RET D631G

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Transcript NM_020975.6
gDNA chr10:g.43114492A>G
cDNA c.1892A>G
Protein p.D631G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43114492A>G c.1892A>G p.D631G RefSeq GRCh38/hg38
NM_020630 chr10:g.43114492A>G c.1892A>G p.D631G RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114492A>G c.1892A>G p.D631G RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114492A>G c.1892A>G p.D631G RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114492A>G c.1892A>G p.D631G RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114492A>G c.1892A>G p.D631G RefSeq GRCh38/hg38
NM_020975 chr10:g.43114492A>G c.1892A>G p.D631G RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114492A>G c.1892A>G p.D631G RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114492A>G c.1892A>G p.D631G RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114492A>G c.1892A>G p.D631G RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References