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Gene | EML4 RET |
Variant | EML4 - RET |
Impact List | fusion |
Protein Effect | gain of function - predicted |
Gene Variant Descriptions | EML4-RET results from the fusion of EML4 and RET (PMID: 33082208), which results in increased Erk phosphorylation in cultured cells (PMID: 33848463), and therefore, is predicted to lead to a gain of protein function. EML4-RET has been identified in lung cancer (PMID: 33082208, PMID: 31485557, PMID: 30487236). |
Associated Drug Resistance | |
Category Variants Paths |
EML4 mutant EML4 fusion EML4 - RET RET mutant RET act mut EML4 - RET RET mutant RET rearrange RET fusion EML4 - RET |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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