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Gene RET
Variant T636M
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET T636M lies within the transmembrane domain of the Ret protein (UniProt.org). T636M results in increased Ret autophosphorylation and Erk1/2 and S6 phosphorylation, and increased proliferation, migration, and transformation in cultured cells (PMID: 25725622).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET T636M

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Transcript NM_020975.6
gDNA chr10:g.43114507C>T
cDNA c.1907C>T
Protein p.T636M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43114507C>T c.1907C>T p.T636M RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114507C>T c.1907C>T p.T636M RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114507C>T c.1907C>T p.T636M RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114507C>T c.1907C>T p.T636M RefSeq GRCh38/hg38
NM_001406784.1 chr10:g.43123766_43123767delCCinsTG c.1907_1908delCCinsTG p.T636M RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114507C>T c.1907C>T p.T636M RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114507C>T c.1907C>T p.T636M RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114507C>T c.1907C>T p.T636M RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114507C>T c.1907C>T p.T636M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References