Gene Variant Detail

Gene CTNNB1
Variant L487fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions CTNNB1 G487fs results in a change in the amino acid sequence of the Ctnnb1 protein beginning at aa 487 of 781, likely resulting in a truncation of the functional protein (UniProt.org). Due to the loss of multiple armadillo repeats (UniProt.org), L487fs is predicted to confer a loss of function to the Ctnnb1 protein.
Associated Drug Resistance

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Transcript NM_001098210
gDNA chr3:g.(41233801_41233802)
cDNA c.(1459_1458)
Protein p.L487fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001098210 chr3:g.(41233801_41233802) c.(1459_1458) p.L487fs RefSeq GRCh38/hg38
XM_005264886 chr3:g.(41233801_41233802) c.(1459_1458) p.L487fs RefSeq GRCh38/hg38
NM_001904 chr3:g.(41233801_41233802) c.(1459_1458) p.L487fs RefSeq GRCh38/hg38
XM_006712985 chr3:g.(41233801_41233802) c.(1459_1458) p.L487fs RefSeq GRCh38/hg38
NM_001098209 chr3:g.(41233801_41233802) c.(1459_1458) p.L487fs RefSeq GRCh38/hg38
XM_017005738 chr3:g.(41233801_41233802) c.(1459_1458) p.L487fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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Molecular Profile Protein Effect Treatment Approaches
CTNNB1 L487fs loss of function - predicted
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References