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|Gene Variant Descriptions||FOXL2 N109K lies within the fork-head DNA binding region of the Foxl2 protein (UniProt.org). The functional effect of N109K is conflicting as it results in defects in apoptosis (PMID: 24240106), and impaired promoter binding and decreased ability to transactivate target genes in culture in some studies (PMID: 18372316, PMID: 19010791, PMID: 24240106), but in other studies demonstrates transcriptional activity (PMID: 19515849, PMID: 20098707), acetylation, XRCC5/6 affinity, and regulation of non-homologous end joining and homologous recombination similar to wild-type Foxl2 in cell culture (PMID: 32332759), and therefore, its effect on Foxl2 protein function is unknown.|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|