Gene Variant Detail

Gene CTNNB1
Variant T42fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions CTNNB1 T42fs results in a change in the amino acid sequence of the Ctnbb1 protein beginning at aa 42 of 781, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of all armadillo domains of Ctnnb1, T42fs is predicted to confer loss of function to the Ctnnb1 protein (UniProt.org).
Associated Drug Resistance

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Transcript NM_001098210
gDNA chr3:g.41224637_41224638delCA
cDNA c.125_126delCA
Protein p.T42fs*7
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001098209 chr3:g.41224637_41224638delCA c.125_126delCA p.T42fs*7 RefSeq GRCh38/hg38
NM_001098210 chr3:g.41224637_41224638delCA c.125_126delCA p.T42fs*7 RefSeq GRCh38/hg38
NM_001904 chr3:g.41224637_41224638delCA c.125_126delCA p.T42fs*7 RefSeq GRCh38/hg38
XM_017005738 chr3:g.41224637_41224638delCA c.125_126delCA p.T42fs*7 RefSeq GRCh38/hg38
XM_006712985 chr3:g.41224637_41224638delCA c.125_126delCA p.T42fs*7 RefSeq GRCh38/hg38
XM_005264886 chr3:g.41224637_41224638delCA c.125_126delCA p.T42fs*7 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Protein Effect Treatment Approaches
CTNNB1 T42fs loss of function - predicted
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References