Gene Variant Detail

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Gene ROS1
Variant A1964T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 A1964T lies within the protein kinase domain of the Ros1 protein (UniProt.org). A1964T has been identified in sequencing studies (PMID: 22810696), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2022).
Associated Drug Resistance

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Transcript NM_002944.2
gDNA chr6:g.117319918C>T
cDNA c.5890G>A
Protein p.A1964T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011536050.2 chr6:g.117319945C>T c.5890G>A p.A1964T RefSeq GRCh38/hg38
XM_011536050 chr6:g.117319945C>T c.5890G>A p.A1964T RefSeq GRCh38/hg38
XM_017011173 chr6:g.117319876C>T c.5890G>A p.A1964T RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117319918C>T c.5890G>A p.A1964T RefSeq GRCh38/hg38
XM_017011173.1 chr6:g.117319876C>T c.5890G>A p.A1964T RefSeq GRCh38/hg38
NM_002944 chr6:g.117319918C>T c.5890G>A p.A1964T RefSeq GRCh38/hg38

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
ROS1 A1964T unknown