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Gene PTEN
Variant K237fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN K237fs results in a change in the amino acid sequence of the Pten protein beginning at 237 of 403, likely resulting in premature truncation of the functional protein (UniProt.org). K237fs has not been characterized, however, due to the effects of other truncation mutations downstream of K237 (PMID: 10468583), is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN K237fs

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Transcript NM_000314.8
gDNA chr10:g.(87957926_87957927)
cDNA c.(709_708)
Protein p.K237fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.(87957926_87957927) c.(709_708) p.K237fs RefSeq GRCh38/hg38
NM_000314.8 chr10:g.(87957926_87957927) c.(709_708) p.K237fs RefSeq GRCh38/hg38
NM_000314 chr10:g.87957929delG c.711delG p.K237fs*19 RefSeq GRCh38/hg38

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Molecular Profile Protein Effect Treatment Approaches
PTEN K237fs loss of function - predicted Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor PI3K Inhibitor (Pan) PIK3CB inhibitor