Gene Variant Detail

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Gene ROS1
Variant W21*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions ROS1 W21* results in a premature truncation of the Ros1 protein at amino acid 21 of 2347 (UniProt.org). Due to the loss of all known functional domains (UniProt.org), W21* is predicted to lead to a loss of Ros1 protein function.
Associated Drug Resistance

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Transcript NM_002944.2
gDNA chr6:g.117425595C>T
cDNA c.62G>A
Protein p.W21*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011536056.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_017011173 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_017011172.1 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_017011172 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536057.3 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_017011173.1 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536050 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536050.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536055.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536053.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_006715548.4 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536049 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536057 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536056 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536052 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536058 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536049.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536055 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_006715548 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536051 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536054.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536053 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536054 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536058.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536052.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
NM_002944 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
ROS1 W21* loss of function - predicted