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|Gene Variant Descriptions||ABL1 A397P lies within the protein kinase domain of the Abl1 protein (UniProt.org). A397P has been demonstrated to occur as a secondary resistance mutation in the context of BCR-ABL1 (PMID: 24456693), but has not been biochemically characterized and therefore, its effect on Abl1 protein function is unknown (PubMed, Oct 2022).|
|Associated Drug Resistance||Y|
|Category Variants Paths||
ABL1 mutant ABL1 A397P
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|